a Record control number 000323830700008

a ISSN 0333-7308

a Original cataloging agency NEU GrandLibrary

a Language code of text/sound track or separate title eng

a Classification number WM 140

b Item number .C43 2013

a Personal name Bozkurt, Ali,

d Dates associated with a name 1954-

h Medium Electronic Document

a Title Changes in Heart Rate Variability before and after ECT in the Treatment of Resistant Major Depressive Disorder.

c Statement of responsibility, etc Ali Bozkurt, Cem Barcin, Mehmet Isintas, Mehmet Ak, Murat Erdem, K. Nahit Ozmenler.

c Date of publication, distribution, etc 2013.

b Name of publisher, distributor, etc Mediafarm Group,

a Place of publication, distribution, etc Tel Aviv :

a Summary, etc Background: In this study, we aimed to evaluate the effects of electroconvulsive therapy (ECT) on cardiac autonomic functions (CAF) in patients with major depressive disorder (MDD) using heart rate variability (HRV) analysis. Method: Fourteen men joined the study. Nine ECTs were administered. Holter monitoring was performed before treatment and at the end of the first, third and sixth weeks of the treatment. The Hamilton Depression Rating Scale (HAM-D) was used to assess symptom severity. Results: Seven patients responded to ECT. There was a change of 2-hour resting HF, pNN50 and RMSSD scores between week 0 and week 6. This change was not significant after week 1 and week 3. HRV values did not differ when we grouped the patients as responders and non-responders to ECT except the 2-hour resting HF value of responders between week 0 and week 6 and the 24-hour HF value of non-responders between week 1 and week 6. All observed changes showed a decrease in parameters. Overall, the LF/HF ratio did not change significantly in either analysis. HRV values did not correlate with HAM-D scores and no relation was found between treatment response and HRV analysis. After Benferroni-adjustment none of the changes were found statistically significant. Limitations: The limitations of the study are the small sample size and the absence of healthy controls. Conclusions: A consistent change in HRV was not observed in response to ECT in patients with MDD. Accepting the HRV as a promising surrogate marker of autonomic activity, ECT does not cause a significant change in nine male treatment resistant MDD patients cardiac autonomic functions.

a Topical term or geographic name as entry element Psychiatry

a Topical term or geographic name as entry element Near East University Article

a Topical term or geographic name as entry element Yakın Doğu Üniversitesi Makale

a Topical term or geographic name as entry element Electroconvulsive-Therapy

g Relationship information 2013, Vol 50 Issue 1, p40-46

t Title Israel Journal Of Psychiatry And Related Sciences

x International Standard Serial Number 03337308