a Record control number 000251188200041

a ISSN 0301-1623

a Original cataloging agency NEU GrandLibrary

a Language code of text/sound track or separate title eng

a Classification number WJ300

b Item number .S47 2007

a Personal name Islekel, Hüray.

h Medium Electronic Document

a Title Serum and urine cystatin C levels in children with post-pyelonephritic renal scarring: a pilot study.

c Statement of responsibility, etc Hüray Islekel, Alper Soylu, Zekiye Altun, Uluç Yis, Mehmet Turkmen, Salih Kavukcu.

c Date of publication, distribution, etc 2008.

b Name of publisher, distributor, etc Springer,

a Place of publication, distribution, etc Dordrecht :

a Summary, etc Aim We aimed to investigate in children with a history of acute pyelonephritis the influence of unilateral post-pyelonephritic renal scarring detected by DMSA scan on serum (S-CysC) and urine cystatin C (U-CysC) as well as upon other traditional markers of renal damage. Methods Children with DMSA proven pyelonephritis (n = 28) were grouped as either scar [+] (n = 19, unilateral renal scarring) or scar [-] (no scarring, n = 9). The scar [+] group was further divided into scar-1 (differential DMSA uptake, Delta(DMSA) > 10%; n = 8) and scar-2 (Delta(DMSA) > 10%, n = 11) subgroups. S-CysC, serum creatinine, urine NAG, microalbumin, protein, fractional sodium excretion (FENa), tubular phosphate reabsorption (TPR), and U-CysC/Cr were evaluated in all patients. Results Neither S-CysC nor U-CysC were affected by age, height, and weight. scar [+] versus scar [-] groups and scar-1 versus scar-2 subgroups were not different with regard to all studied parameters. S-CysC did not increase in children with post-pyelonephritic unilateral renal scarring. However, 11 children with slightly increased (> 0.95 mg/l) S-CysC levels in scar [+] group tended to have higher Delta(DMSA), albeit not significantly. Furthermore, U-CysC/Cr correlated well with urine microalbumin, NAG, and FENa in all children and the scar [+] group (P < 0.05). Conclusions S-CysC and U-CysC did not differ among pediatric patients with and without unilateral post-pyelonephritic renal scarring. However, Delta(DMSA) uptake between the two kidneys tended to be raised in children with S-CysC levels higher than the reference ranges. Additionally, U-CysC/Cr exhibits parallelism with tubular functions.

a Topical term or geographic name as entry element Urology & Nephrology

a Topical term or geographic name as entry element Near East University Article

a Topical term or geographic name as entry element Yakın Doğu Üniversitesi Makale

a Topical term or geographic name as entry element Glomerular-Filtration-Rate

a Topical term or geographic name as entry element Molecular-Weight Proteinuria

a Main entry heading International Urology And Nephrology

g Relationship information DEC 2007, Vol 39 Issue 9, p1241-1250

x International Standard Serial Number 03011623

u Uniform Resource Identifier http://library.neu.edu.tr:2048/login?url=http://dx.doi.org/10.1007/s11255-007-9260-4