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Expression of TRF2 and its prognostic relevance in advanced stage cervical cancer patients (Ozden, Sevgi.)
Bibliographical information (record 264004)
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Expression of TRF2 and its prognostic relevance in advanced stage cervical cancer patients
Author:
 Ozden, Sevgi. Search Author in Amazon Books

Publisher:
Socbıolgıa Chıle,
Edition:
 2014.
Classification:
 WP470
URL:
http://library.neu.edu.tr:2048/login?url=http://dx.doi.org/10.1186/0717-6287-47-61
Detailed notes
    - Background: Telomeres are protective caps consisted of specific tandem repeats (5 '-TTAGGG-3 '). Shortening of telomeres at each cell division is known as "mitotic clock" of the cells, which renders telomeres as important regulators of lifespan. TRF2 is one of the critical members of shelterin complex, which is a protein complex responsible from the preservation of cap structure, and loss or mutation of TRF2 results in DNA damage, senescence or apoptosis. Since cancer is frequently associated with aberrant cell cycle progression, defective DNA repair or apoptosis pathways, TRF2 could be one likely candidate for cancer therapy.
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Status
Library
Section
EOL-411
Item available
NEU Grand LibraryOnline (WP470 .E97 2014)
Online electronic
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