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C-Met expression pattern in uterine leiomyoma (Boynukalin, F. K.)
Bibliographical information (record 264360)
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C-Met expression pattern in uterine leiomyoma
Author:
 Boynukalin, F. K. Search Author in Amazon Books

Publisher:
I r o g Canada, Inc
Edition:
 2014.
Classification:
 WP120
Detailed notes
    - Aim: Growth factors take place in the formation and growth of uterine leiomyomas (LMs). Transforming growth factor beta (TGF-beta), epidermal growth factor (EGF), platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF), fibroblast growth factor-2 (FGF-2), and insulin-like growth factor (IGF) contribute to the pathophysiology of LMs when they bind with a specific membrane receptor and transmit a signal into the cell. Little is known about hepatocyte growth factor (HGF) and its receptor system c-Met in formation and growth of uterine LMs. The aim of this study was to evaluate the c-Met receptor expression on human myometrium and uterine LMs. Materials and Methods: The study was performed on human myometrium and uterine LMs. Expression of c-Met receptor was evaluated by immunohistochemical analysis. Results: Overexpression of c-Met was found in all LM cases and in none of normal myometrium samples c-Met overexpression was seen. Conclusion: HGF and c-Met receptor complex seem to have role in development of uterine LMs.
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Status
Library
Section
EOL-495
Item available
NEU Grand LibraryOnline (WP120 .M48 2014)
Online electronic
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