|
|
|
|
|
Assessment of Protective Effects of Methylprednisolone and Pheniramine Maleate on Reperfusion Injury in Kidney After Distant Organ Ischemia: A Rat Model
(Bayrak, Serdar.) |
|
|
|
Bibliographical information (record 264595) |
|
|
- Background: Ischemia/reperfusion (I/R) injury of tissues is a common problem that cardiovascular surgeons are faced with. Suppression of inflammation, which plays an important role in the pathogenesis of I/R injury, may reduce this damage. The aim of this study is to investigate the protective effects of methylprednisolone (MP)-a potent anti-inflammatory agent-and pheniramine maleate (FM)-an antihistamine that also has some anti-inflammatory effects-on reperfusion injury of kidneys developing after ischemia of the left lower extremity of rats.Methods: Twenty-eight randomly selected male Sprague-Dawley rats weighing 320 to 370 g were divided into four groups, each consisting of seven rats. Group 1 was the control group. Group 2 was the sham group. Rats in group 3 were subjected to I/R and given FM, and rats in group 4 were subjected to I/R and given MP. A tourniquet was applied at the level of the left groin to subjects in group 2 after induction of anesthesia. One hour of ischemia was performed, and no drug was administered. In group 3, half of a total dose of 10 mg/kg FM was administered before ischemia, and the remaining half was given intraperitoneally before reperfusion. In group 4, subjects received a single dose of 50 mg/kg MP intraperitoneally in the 30th minute of ischemia. Kidneys of all subjects were removed after 24 hours. Extracted tissues were investigated regarding histological and biochemical parametersResults: Malondialdehyde -the end product of lipid peroxidation as an important indicator of I/R injury-levels were significantly lower in group 3 than in group 2 (P < 0.05). Malondialdehyde levels were also lower in group 4 than in group 2, but this difference was insignificant (P > 0.05). Superoxide dismutase and glutathione peroxidase enzyme activities were found to be significantly higher in group 3 than in group 2 (P < 0.05). However, there was no difference between group 4 and group 2 in terms of these activities. Histological examination demonstrated that both MP and FM had protective effects against I/R injury, but this effect was more potent for FM than for MP.Conclusions: FM has a protective effect against reperfusion injury in rat kidney after distant organ ischemia.
|
|
|
|
|
Barcode |
Status |
Library |
Section |
|
EOL-140
|
Item available
|
NEU Grand LibraryOnline (WG100 .A87 2012)
|
Online electronic |
|
|
Search Author in Amazon Books
