- Six cycloartane-type triterpene glycosides were isolated from Astragalus stereocalyx along with six
known cycloartane-type glycosides. Their structures were established by the extensive use of 1D
and 2D-NMR experiments along with ESIMS and HRMS analysis. Three compounds are based on an
aglycon characterized by the occurrence of an unusual hydroxyl group at position 20, whereas three
other compounds are based on cycloasgenin C as aglycon, so far reported from Astragalus spp. All the
compounds were tested for their cytotoxic activity against a number of cancer cell lines. One compound
exhibited activity versus human cervical cancer (Hela) with an IC50 value = 10 lM.
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