Flavonoids from Sideritis Species: Human Monoamine Oxidase
(hMAO) Inhibitory Activities, Molecular Docking Studies and
Crystal Structure of Xanthomicrol
(Turkmenoglu, Fatma Pinar.)
Bibliographical information (record 265197)
Flavonoids from Sideritis Species: Human Monoamine Oxidase
(hMAO) Inhibitory Activities, Molecular Docking Studies and
Crystal Structure of Xanthomicrol
- The inhibitory effects of flavonoids on monoamine oxidases (MAOs) have
attracted great interest since alterations in monoaminergic transmission are reported to be
related to neurodegenerative diseases such as Parkinson’s and Alzheimer’s diseases and
psychiatric disorders such as depression and anxiety, thus MAOs may be considered as
targets for the treatment of these multi-factorial diseases. In the present study, four Sideritis
flavonoids, xanthomicrol (1), isoscutellarein 7-O-[6'''-O-acetyl-β-D-allopyranosyl-(1→2)]-
β-D-glucopyranoside (2), isoscutellarein 7-O-[6'''-O-acetyl-β-D-allopyranosyl-(1→2)]-6''-O- acetyl-β-D-glucopyranoside (3) and salvigenin (4) were docked computationally into the
active site of the human monoamine oxidase isoforms (hMAO-A and hMAO-B) and were
also investigated for their hMAO inhibitory potencies using recombinant hMAO
isoenzymes. The flavonoids inhibited hMAO-A selectively and reversibly in a competitive
mode. Salvigenin (4) was found to be the most potent hMAO-A inhibitor, while
xanthomicrol (1) appeared as the most selective hMAO-A inhibitor. The computationally
obtained results were in good agreement with the corresponding experimental values. In
addition, the x-ray structure of xanthomicrol (1) has been shown. The current work warrants
further preclinical studies to assess the potential of xanthomicrol (1) and salvigenin (4) as
new selective and reversible hMAO-A inhibitors for the treatment of depression and anxiety.
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