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Is the interchromosomal effect present in embryos derived from
Robertsonian and reciprocal translocation carriers particularly
focusing on chromosome 10 rearrangements?
(Tülay, Pınar,) |
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Bibliographical information (record 265234) |
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Is the interchromosomal effect present in embryos derived from
Robertsonian and reciprocal translocation carriers particularly
focusing on chromosome 10 rearrangements? |
Author:
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Tülay, Pınar,
Search Author in Amazon Books
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Publisher: |
PubMed,
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Edition: |
2014.
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Classification: |
QZ50 |
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- The aim of this study was to analyse the possible occurrence of the interchromosomal effect (ICE)
in human preimplantation embryos obtained from Robertsonian and reciprocal translocation carriers
focusing on ones with chromosome 10 rearrangements who were undergoing preimplantation genetic
diagnosis (PGD) and to investigate whether offering aneuploidy screening would be beneficial to
these patients. Cleavage stage embryos from translocation carriers undergoing PGD were biopsied.
Multicolour fluorescence in situ hybridisation for the chromosomes involved in the translocation in
addition to nine more chromosomes (13, 15, 16, 17, 18, 21, 22, X and Y) was used in the analysis.
The control group involved embryos obtained from age-matched patients undergoing preimplantation
genetic screening (PGS). Cumulative aneuploidy rate in embryos derived from both Robertsonian and
reciprocal translocation carriers was found to be similar with the control group. Therefore no ICE was
observed in cleavage stage embryos obtained from these carriers. More than half of the embryos with
chromosome 10 rearrangements had aneuploidy for which an increased aneuploidy rate was more
apparent in male carriers. Thus, it is possible that there is a risk of ICE in reciprocal carriers with
chromosome 10 rearrangements. This study showed that there is no ICE in embryos derived from
Robertsonian and reciprocal translocation carriers. However high rates of aneuploidy in structurally
normal chromosomes were detected in embryos derived from these carriers and thus aneuploidy
screening in addition to PGD may increase the pregnancy rates of these patients.
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Library |
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EOL-754
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Item available
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NEU Grand LibraryOnline (QZ50 .I8 2014)
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Online electronic |
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