Poor embryo development and preimplantation genetic diagnosis
outcomes of translocations involving chromosome 10: Do we blame
genetics?
(Tülay, Pınar,)
Bibliographical information (record 265240)
Poor embryo development and preimplantation genetic diagnosis
outcomes of translocations involving chromosome 10: Do we blame
genetics?
- Balanced reciprocal translocation carriers are usually phenotypically normal. Although the reproductive
risk of these carriers varies, they generally have a lower chance to produce normal or balanced
gametes. Preimplantation genetic diagnosis (PGD) is offered to these patients to increase their chances
of becoming pregnant by selecting a balanced embryo for transfer. This study aimed to analyse the
development and the PGD outcome of the embryos obtained from reciprocal translocation carriers
focusing on ones with chromosome 10 rearrangements. In total, 27 reciprocal translocation carriers
underwent 31 cycles of PGD. PGD was performed using multicolour fluorescence in situ hybridisation
for 298 embryos and of these 136 were obtained from couples carrying translocations involving
chromosome 10 rearrangements. Carriers of translocations involving chromosome 10 rearrangements
have a lower chance of producing normal or balanced embryos compared with the carriers with
other rearrangements. The development of embryos obtained from the patients with chromosome 10
rearrangements was impaired and only a limited number of embryos developed to the blastocyst stage.
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