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The Role of Homocysteine in Tinnitus Etiology (Inancli, Hasan Mete.)

Bibliographical information (record 265873)

The Role of Homocysteine in Tinnitus Etiology
Author:	Inancli, Hasan Mete. Search Author in Amazon Books
Publisher:	Mediterranean Soc Otology & Audiology,

Edition:	2011.
Classification:	WV100.3

Detailed notes

- Objectives: The aim of this study is to determine the relationship between homocysteine levels and tinnitus.Methodology: Ninety-nine patients admitted to our clinic with the complaint of tinnitus between June 2004 and January 2007 were included in our study. The patients were divided into four groups; Group 1 and 2: tinnitus with/without coexisting diseases, Group 3 and 4 tinnitus with/without hearing loss. Group 1 includes patients with tinnitus and coexisting disease, and Group 2 includes patients with tinnitus without any other coexisting disease. Group 3, includes patients with tinnitus and hearing loss and Group 4 includes patients with tinnitus without hearing loss. Plasma homocysteine and vitamin B12 levels were detected and compared among these four groups.Results: The ages of the 99 subjects were between 19-70 (mean age 49.48 years); 62 were male and 37 female. Of the 99 patients with tinnitus, 43 (43.4%) were in group A, 56 (56.5%) in group B. The most frequent coexisting disease was hypertension, followed by diabetes mellitus and dyslipidemia which was detected by an internal medicine specialist. When group 1 was compared with group 2 and group 3 with group 4, there was no statistically significant difference in the homocysteine and vitamin B12 levels between the groups.Conclusion: Our study found no statistically significant difference between patient groups in regard to the plasma levels of homocysteine and vitamin B(12). Their role in the etiology and therapy of tinnitus may need further investigation.