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Evidence for oxidative stress in the hepatic mitochondria of bile duct ligated rats. (Alptekin, N.)
Bibliographical information (record 270258)
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Evidence for oxidative stress in the hepatic mitochondria of bile duct ligated rats.
Author:
 Alptekin, N. Search Author in Amazon Books

Publisher:
Elsevier,
Edition:
 1997.
Classification:
 QV 4
URL:
http://library.neu.edu.tr:2048/login?url=http://dx.doi.org/10.1006/phrs.1997.0225
Detailed notes
    - Lipid peroxidation increased both in the liver homogenates and in the hepatic mitochondrial fraction of bile duct ligated (BDL)-rats. Although mitochondrial superoxide dismutase (SOD) activity did not change in the liver, glutathione (GSH) levels and glutathione peroxidase (GSH-Px) activity decreased in hepatic mitochondrial fraction of BDL-rats as compared to sham-operated rats. In addition, GSH-Px and glutathione transferase (GST) activities decreased but SOD activity remained unchanged in the post-mitochondrial fraction of the liver from BDL-rats. However, erythrocyte lipid peroxide and GSH levels did not change in BDL-rats. In conclusion, our results show that the disturbance of oxidant-antioxidant balance especially in mitochondria may be responsible for cholestatic injury in BDL-rats. (C) 1997 The Italian Pharmacological Society.
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Section
EOL-1768
Item available
NEU Grand LibraryOnline (QV 4 .E95 1997)
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