Statement of the Problem: When adhesive restorations are used in combination with bleaching in clinical applications, it is generally recommended to wait for a period of time between the two procedures. However, it is not clear if a time interval is necessary between applying the bleaching treatments and the silorane-based restorative system. Purpose: The purpose of this in vitro study was to determine if activated bleaching affects the bond strength of silorane-based restorative, a newly developed restorative that uses a polymerization system that has been reported to be insensitive to oxygen. Methods: A gel consisting of 38% hydrogen peroxide was applied to ground labial enamel surfaces and activated using a diode laser to bleach the teeth. Then, without waiting for any period of time, four different restorative materials were applied to the bleached enamel surfaces, and these sets were compared with nonbleached control samples. The shear bond strength of the restorative systems to enamel was tested, and data was evaluated using two-way analysis of variance and Tukey HSD tests. Results: Significant differences (p < 0.05) in shear bond strengths were found among bleached and nonbleached enamel surfaces. Conclusion: It may be more beneficial to allow a time interval of 2 to 3 weeks between activated hydrogen peroxide bleaching and applying silorane-based composite restoratives or methacrylate-based composites than just applying restorative agents immediately after bleaching. However, further studies are needed to examine the structural effects of activated hydrogen peroxide on enamel.