Amitriptyline may have a supportive role in cancer treatment by inhibiting glutathione S-transferase pi (GST-pi) and alpha (GST-alpha) (Kayıt no. 242593)
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|---|---|
| fixed length control field | naa a22 7ar4500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20151027110733.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 150528t xxu||||| |||| 00| 0 tu d |
| 001 - CONTROL NUMBER | |
| control field | 265907 |
| 016 ## - NATIONAL BIBLIOGRAPHIC AGENCY CONTROL NUMBER | |
| Record control number | 000313663400016 |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER | |
| International Standard Serial Number | 1475-6366 |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | NEU |
| 041 ## - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 050 04 - LIBRARY OF CONGRESS CALL NUMBER | |
| Classification number | QU4 |
| 100 1# - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 574751 |
| Personal name | Kulaksiz-Erkmen, Gulnihal. |
| 245 10 - TITLE STATEMENT | |
| Title | Amitriptyline may have a supportive role in cancer treatment by inhibiting glutathione S-transferase pi (GST-pi) and alpha (GST-alpha) |
| Statement of responsibility, etc. | Gülnihal Kulaksiz-Erkmen, Özlem Dalmizrak, Gamze Dincsoy-Tuna, Arın Doğan, I. Hamdi Oğuş, Nazmi Özer |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Name of publisher, distributor, etc. | Informa Healthcare, |
| Date of publication, distribution, etc. | 2013. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | A tricyclic anti-depressant, amitriptyline, is a highly prescribed drug for cancer patients for mood elevation but there are limited studies about the interaction of amitriptyline with glutathione S-transferases pi (GST-pi) and glutathione S-transferases alpha (GST-alpha). GST isozymes have been implicated in chemotherapeutic drug resistance. We demonstrated that the concentration dependent inhibition of GST-pi and GST-alpha by amitriptyline followed inverse hyperbolic inhibition curves with IC50 values of 5.54 and 8.32 mM, respectively. <br/><br/>When the varied substrate was GSH, amitriptyline inhibited both isozymes competitively and similar K-i values were found for GST-pi (K-i = 1.61 +/- 0.17 mM) and GST-alpha (K-i = 1.45 +/- 0.20 mM). On the other hand, when the varied substrate was CDNB, the inhibition types were non-competitive for GST-pi (K-i = 1.98 +/- 0.31 mM) and competitive for GST-alpha (K-i = 1.57 +/- 0.16 mM). <br/><br/>Amitriptyline, in addition to its antidepressant effect, might also have a minor supportive role on the effectiveness of the anticancer drugs by decreasing their elimination through inhibiting GST-pi and GST-alpha. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 572720 |
| Topical term or geographic name entry element | Near East University Article |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 572723 |
| Topical term or geographic name entry element | Yakın Doğu Üniversitesi Makale |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 117600 |
| Topical term or geographic name entry element | Biochemistry |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 574753 |
| Topical term or geographic name entry element | anticancer drugs; |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 574754 |
| Topical term or geographic name entry element | GST-alpha; |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 574755 |
| Topical term or geographic name entry element | Serotonın |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 574756 |
| Topical term or geographic name entry element | Transporters |
| 773 ## - HOST ITEM ENTRY | |
| Related parts | Feb 2013, Volume: 28, Issue:1, Pages: 131-136 |
| Title | Journal Of Enzyme Inhıbıtıon And Medıcınal Chemıstry |
| International Standard Serial Number | 14756366 |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://library.neu.edu.tr:2048/login?url=http://dx.doi.org/10.3109/14756366.2011.639017 ">http://library.neu.edu.tr:2048/login?url=http://dx.doi.org/10.3109/14756366.2011.639017 </a> |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| -- | 1000005 |
| Call number prefix | QU0000004A452013 |
| Koha item type | Online Electronic Document |
| Total checkouts | Full call number | Barcode | Koha item type | Lost status | Damaged status | Not for loan | Withdrawn status | Home library | Current library | Shelving location |
|---|---|---|---|---|---|---|---|---|---|---|
| QU4 .A45 2013 | EOL-921 | Online Electronic Document | NEU Grand Library | NEU Grand Library | Online electronic |