Evaluation of the in vitro Inhibitory Impact of Hypericin on Placental Glutathione S-Transferase pi. (Kayıt no. 244376)
[ düz görünüm ]
| 000 -LEADER | |
|---|---|
| fixed length control field | naa a22 7ar4500 |
| 016 ## - NATIONAL BIBLIOGRAPHIC AGENCY CONTROL NUMBER | |
| Record control number | 000307981500002 |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER | |
| International Standard Serial Number | 1572-3887 |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | NEU |
| 041 ## - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 050 ## - LIBRARY OF CONGRESS CALL NUMBER | |
| Classification number | QU4.3 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20160223114342.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 150427t xxu||||| |||| 00| 0 tu d |
| 001 - CONTROL NUMBER | |
| control field | 267712 |
| 100 1# - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 574912 |
| Personal name | Dalmızrak, Özlem, |
| Titles and words associated with a name | Prof. Dr. |
| -- | |
| 245 10 - TITLE STATEMENT | |
| Title | Evaluation of the in vitro Inhibitory Impact of Hypericin on Placental Glutathione S-Transferase pi. |
| Statement of responsibility, etc. | Ozlem Dalmizrak, Gulnihal Kulaksiz, Erkmen Nazmi Ozer. |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Date of publication, distribution, etc. | 2012. |
| Name of publisher, distributor, etc. | Springer, |
| Place of publication, distribution, etc. | New York : |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | St John's Wort (SJW) extracts are herbal products which are available without prescription in most countries and widely used in the treatment of mild to moderate depression. Since it is a herbal product and available without prescription, use of SJW is common among pregnant and/or lactating woman. The principal of the study was to clarify the effects of hypericin, one of the components of SJW, on glutathione S-transferase-pi (GST-pi) purified from human placenta. The K (m) values of GST-pi were 0.21 +/- A 0.03 mM for glutathione (GSH) and 2.29 +/- A 0.54 mM for 1-chloro-2,4-dinitrobenzene (CDNB). At fixed [GSH], the V (m) value calculated was about 3 times higher than the conditions in which [CDNB] was fixed; 201 +/- A 30 U/mg protein versus 74 +/- A 3 U/mg protein. At constant substrate concentrations (1 mM), an average IC (50) value of 0.70 +/- A 0.02 mu M was obtained. Hypericin inhibited GST-pi competitively with respect to both substrates. When GSH was the varied substrate a K (i) value of 0.31 +/- A 0.05 mu M was found; when CDNB was the varied substrate, a K (i) value of 0.85 +/- A 0.02 mu M was obtained. On the basis of these data considering transplacental transfer of hypericin and immature hepatic clearance of the baby, using this herbal product may cause abnormalites due to the inhibition of one of the most important placental detoxification enzymes, GST-pi.<br/> |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 117600 |
| Topical term or geographic name entry element | Biochemistry |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 572720 |
| Topical term or geographic name entry element | Near East University Article |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 572723 |
| Topical term or geographic name entry element | Yakın Doğu Üniversitesi Makale |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 576675 |
| Topical term or geographic name entry element | Inhibition kinetics |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 576676 |
| Topical term or geographic name entry element | St John's Wort |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 576677 |
| Topical term or geographic name entry element | Transplacental transfer |
| 773 ## - HOST ITEM ENTRY | |
| Main entry heading | Protein Journal |
| Related parts | OCT 2012, Vol 31 Issue 7, p544-549 |
| International Standard Serial Number | 15723887 |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://library.neu.edu.tr:2048/login?url=http://dx.doi.org/10.1007/s10930-012-9433-6 ">http://library.neu.edu.tr:2048/login?url=http://dx.doi.org/10.1007/s10930-012-9433-6 </a> |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| -- | 1000007 |
| Call number prefix | QU00000043E932012 |
| Koha item type | Online Electronic Document |
| Total checkouts | Full call number | Barcode | Koha item type | Lost status | Damaged status | Not for loan | Withdrawn status | Home library | Current library | Shelving location |
|---|---|---|---|---|---|---|---|---|---|---|
| QU4.3 .E93 2012 | EOL-1564 | Online Electronic Document | NEU Grand Library | NEU Grand Library | Online electronic |