Clustering of organ-specific autoimmunity: a case presentation of multiple sclerosis and connective tissue disorders Nilufer Kale, Murat Icen, Jale Agaoglu, Isil Yazici, Osman Tanik.

By:

Kale, Nilufer

Material type: Article

ArticleLanguage: English Publication details: 2008. Elsevier, New York :ISSN:

1590-1874

Subject(s):

LOC classification:

WL100.3

Online resources:

Click here to access online

In: Neurological Sciences DEC 2008 , Vol 29 Issue 6, p471-475 Summary: Multiple sclerosis (MS) is the most common demyelinating disease caused by an autoimmune inflammatory process in the central nervous system (CNS) and is associated with aberrant immune response to myelin selfantigens. Coexistence of MS with other autoimmune disorders, including connective tissue disorders including systemic lupus erythematosus, rheumatoid arthritis, Sjogren's syndrome and scleroderma have been reported previously. In the present article we report the coexistence of MS, familial mediterranean fever and ankylosing spondylitis in a patient and review the clinical presentation, neurologic findings, cerebrospinal fluid and radiologic characteristics and treatment options. We further discuss the immunopathogenetic mechanisms for a possible association between MS and autoimmune disorders.

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Holdings
Item type	Current library	Call number	Status	Barcode
Online Electronic Document	NEU Grand Library Online electronic	WL100.3 .C58 2008 (Browse shelf(Opens below))	Not for loan	EOL-1329

Multiple sclerosis (MS) is the most common demyelinating disease caused by an autoimmune inflammatory process in the central nervous system (CNS) and is associated with aberrant immune response to myelin selfantigens. Coexistence of MS with other autoimmune disorders, including connective tissue disorders including systemic lupus erythematosus, rheumatoid arthritis, Sjogren's syndrome and scleroderma have been reported previously. In the present article we report the coexistence of MS, familial mediterranean fever and ankylosing spondylitis in a patient and review the clinical presentation, neurologic findings, cerebrospinal fluid and radiologic characteristics and treatment options. We further discuss the immunopathogenetic mechanisms for a possible association between MS and autoimmune disorders.

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