Izgut-Uysal, V. Nimet. <br/><br/>
The protective effect of apelin against water-immersion and restraint stress-induced gastric damage  
V. Nimet Izgut-Uysal, Burcu Gemici, Ilknur Birsen, Nuray Acar, Ismail Ustunel.  
 - Springer Japan KK,  Tokyo  2014. 
<br/><br/> The aim of the present study was to investigate the gastroprotective effect of apelin on water-immersion and restraint stress (WIRS)-induced gastric lesions. Male Wistar rats were divided into four groups: control, WIRS, F13A + WIRS and F13A. APJ receptor antagonist F13A was administered to rats to determine the influence of apelin on stress-induced gastric injury. WIRS administered for 6 h resulted in the development of gastric mucosal lesions accompanied by a significant increase in plasma corticosterone. WIRS increased the concentration of 4-hydroxynonenol (4-HNE) + malondialdehyde (MDA) and the expression of apelin and hypoxia inducible factor-1 alpha (HIF-1 alpha) in gastric mucosa. In addition, WIRS reduced the mucosal blood flow and gastric prostaglandin E-2 (PGE(2)) concentration. Plasma corticosterone, which was increased due to stress, was significantly decreased in the F13A + WIRS group. Gastric lesions and the 4-HNE + MDA concentration were also higher in the F13A + WIRS compared to the WIRS group. We conclude that apelin has a gastroprotective effect against stress-induced lesions possibly by reducing lipid peroxidation in gastric mucosa. 
<br/><br/><label>ISSN: </label>1880-6546  
<br/><br/><label>Nat. Bib. Agency Control No.: </label>WOS:000338504300006  
<br/><br/><label>Subjects--Topical Terms: </label><br/>Physiology<br/>Near East University Article<br/>Yakın Doğu Üniversitesi Makale<br/>Gastric mucosal injury<br/>Apelin<br/>APJ antagonist<br/>  Receptor Messenger-RNA 
<br/><br/><label>LC Class. No.: </label>QT104