Karakoc-Aydiner, Elif. <br/><br/>
An Adolescent with Hyperimmunoglobulinemia D and Periodic Fever Syndrome Responding to Simvastatin Treatment. 
Safa Baris, Elif Karakoc-Aydiner, Nerin N.  Bahceciler, Isil Barlan, Cevdet  Ozdemir, Sevgi Keles. 
 - Ankara :  Turkish League Against Rheumatism,  2011. 
<br/><br/> The hyperimmunoglobulinemia D and periodic fever syndrome is proposed to be caused by a defect in the activity of mevalonate kinase enzyme which is involved in cholesterol and non-sterol isoprenoid biosynthesis. This autosomal recessive inherited auto-inflammatory syndrome is characterized by recurrent fever attacks, abdominal pain, lymphadenopathy, skin lesions and joint involvement. In this article, we present our therapeutic approach with the hypolipidemic agent, simvastatin, in a 12-year-old boy followed up with a diagnosis of hyperimmunoglobulinemia D and periodic fever syndrome. Simvastatin treatment of an adolescent with hyperimmunoglobulinemia D and periodic fever syndrome unresponsive to anti-inflammatory strategies has resulted in a favorable outcome. This treatment is thought to reduce the recurrent fever attacks by reducing the mevalonic acid increase or isopreniod shortage. 
<br/><br/><label>ISSN: </label>1309-0291 
<br/><br/><label>Nat. Bib. Agency Control No.: </label>000295972800013  
<br/><br/><label>Subjects--Topical Terms: </label><br/>Near East University Article<br/>Yakın Doğu Üniversitesi Makale<br/>Rheumatology.<br/>Hyperimmunoglobulinemia D<br/>Periodic fever syndrome
<br/><br/><label>LC Class. No.: </label>WE 544